Aspirin has analgesic (pain killing), antipyretic (reduces temperature) and anti-inflammatory actions. It also has a blood thinning action, which has been shown to be useful following myocardial infarction, and in patients with unstable angina or ischaemic stroke.

Why have I been prescribed Aspirin?

  • Aspirin has analgesic (pain killing), antipyretic (reduces temperature) and anti-inflammatory actions. It also has a blood thinning action, which has been shown to be useful following myocardial infarction, and in patients with unstable angina or ischaemic stroke.
  • When taken regularly Nu-Seals 300mg can reduce the risk of blood clots forming and can prevent further heart attacks or strokes.
  • Nu-Seals 300 is used wherever high and prolonged dosage of aspirin is required.
It is unsuitable for the short-term relief of pain.

How does it work?

  • Aspirin prevents the production of certain chemicals (prostaglandins) which are associated with pain, fever and inflammation.
  • Platelets are the part of the blood which clump together to form a scab when you cut yourself.
  • They can also clump together in the arteries and form clots which can block the flow of blood and oxygen.
  • This may cause heart attackangina or stroke. Aspirin stops this happening making the blood thinner and flow easier.

When and how do I take it?

  • Always take Aspirin exactly as your doctor has told you. You should check with your doctor or pharmacist if you are not sure.
  • If you take these tablets over a long period of time, your doctor may want to review your dose regularly, particularly if you are elderly.
  • Swallow the tablet whole with water. Do not cut, crush or chew it.

What’s the dose?

  • Anti-platelet’ action (for people who have had heart attacks, angina or mini strokes): take one 300mg tablet a day.
  • For pain and swelling, or fever: take up to three 300mg tablets 3 or 4 times a day.
  • Acute rheumatic disorders: your doctor will tell you how many tablets to take and how often. You will usually take 4 to 8 grams of Nu-Seals 300mg a day.
  • There is a possible association between Aspirin and Reye's syndrome when given to children. Reye's syndrome is a very rare disease which affects both the brain and the liver and can be fatal. For this reason it should not normally be given to children and adolescents aged under 16 years except on medical advice.

Could they interact with other tablets?

The effect of treatment may be influenced if Aspirin is taken at the same time as some other medicines for:

  • Thinning of the blood/prevention of clots (e.g. warfarin),
  • Organ rejection after transplantation (e.g. cyclosporin, tacrolimus),
  • High blood pressure (e.g. diuretics and ACE-inhibitors),
  • Pain and inflammation (e.g. anti-inflammatory medicines such as ibuprofen, or steroids),
  • Gout (e.g. probnecid),
  • Cancer or rheumatoid arthritis (e.g. methotrexate),
  • antiplatelet agents (e.g. clopidogrel and dipyridamole),
  • diuretics (water tablets),
  • cardiac glycosides (drugs which regulate the heart beat),
  • lithium,
  • corticosteroids,
  • aminoglycosides (a group of antibiotics),
  • phenytoin,
  • sodium valproate,
  • sulphonamides,
  • selective serotonin re-uptake inhibitors (SSRIs) for depression such as sertraline or paroxetine.

Before using Aspirin you should inform a healthcare professional about the medicines you are taking. If you are using Aspirin regularly you should seek advice before taking any other medicine including medicines obtained without a prescription.

Herbal supplements should be used with caution and only after informing your doctor first.

What are the possible risks or side-effects?

Like all medicines, Aspirin can cause side effects, although not everybody gets them. The special coating on Aspirin is intended to stop the Aspirin from irritating the stomach.

You will probably notice you bleed a lot easier and for longer, if for example you cut yourself shaving, or cut your hand with a knife. This is normal. However you must look out for any unexplained bleeding eg blood in urine or stools or persistent nose bleeds. Alert your doctor if notice any bleeding like this you are worried about.

The more common side-effects include:

  • hypersensitivity (which may mean you have skin rashes or itching, or wheezing, coughing or difficulty breathing);
  • feeling sick or actually being sick;
  • diarrhoea;
  • flatulence;
  • constipation;
  • worsening of colitis, Crohn’s disease or irritation of your colostomy;
  • ringing in your ears; and
  • stomach ulcer which can cause stomach pain or discomfort in your stomach or lower chest after eating.

Aspirin may sometimes cause asthma or bronchospasm (wheezing or difficulty in breathing).

Can I drink alcohol while taking it?

It's normally safe to drink alcohol when taking Aspirin as long as you drink within the recommended daily amount (between 3-4 units a day for men and between 2-3 units a day for women). However you are more likely to get gastrointestinal side effects if you drink alcohol while taking Aspirin.Always ask your doctor or pharmacist first because this may depend on what other tablets you are taking.

What if I’m pregnant/breastfeeding?

Analgesic doses of Aspirin should be avoided during the last trimester of pregnancy.
As Aspirin is secreted into breast milk, Aspirin should not be taken by patients who are breast-feeding, as there is a risk of Reye's syndrome in the infant.

If you have any more questions please ask your Pharmacist.

Remember to keep all medicines out of reach of children
Please Note:
 We have made every effort to ensure that the content of this information sheet is correct at time of publish, but remember that information about drugs may change. This sheet does not list all the uses and side-effects associated with this drug. For full details please see the drug information leaflet which comes with your medicine. Your doctor will assess your medical circumstances and draw your attention to any information or side-effects which may be relevant in your particular case.



Health Reference: Heart attack, Angina, Stroke

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